Visual pathway neurodegeneration winged by mitochondrial dysfunction
نویسندگان
چکیده
منابع مشابه
Visual pathway neurodegeneration winged by mitochondrial dysfunction
OBJECTIVES To test for structural and functional contribution of mitochondrial dysfunction to neurodegeneration in multiple sclerosis (MS). A visual pathway model void of MS lesions was chosen in order to exclude neurodegeneration secondary to lesion related axonotmesis. METHODS A single-centre cohort study (230 MS patients, 63 controls). Spectral domain optical coherence tomography of the re...
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The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). One example of this is mitochondria...
متن کاملTopic: Mitochondrial Dysfunction in Neurodegeneration
Neurodegenerative diseases such as Parkinson's disease (PD) are of growing public health concern in developed countries and the need for novel effective treatments continues to increase. Neurodegenerative diseases take many forms, reflecting the degeneration of different populations of neurons at different times from distinct causes, but many of them also share common features. Amongst the comm...
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1 Laboratory of Bioenergetics, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil 2 Department of Cellular Signaling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland 3Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, M...
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ژورنال
عنوان ژورنال: Annals of Clinical and Translational Neurology
سال: 2014
ISSN: 2328-9503
DOI: 10.1002/acn3.157